Boehringer Ingelheim and Exputec: Scale-up and scale-down of biopharmaceutical processes

Boehringer Ingelheim and Exputec: Scale-up and scale-down of biopharmaceutical processes

In a joint talk, Sandra Abad from Boehringer Ingelheim and Patrick Sagmeister from Exputec presented at the 4th BioProScale conference in Berlin, Germany, how scale-dependent challenges were overcome for the successful scale-up of a biopharmaceutical manufacturing process and the qualification of scale-down models. This was achieved using data science workflows including

  1. Similarity analysis for the qualification of scale-down models,
  2. Root cause analysis based on automatic information mining and multivariate analysis and
  3. Improvement of scale-up based on industrial best practices and simulation models.

Sandra Abad demonstrated, how Boehringer Ingelheim expends its technological leadership for safe, compliant and predictable scale-up of bioprocesseses based on cutting-edge data science technologies.

More information on applied technologies you find here:  inCyght Bioprocess Analysis Platform

Sandra Abad from Boehringer Ingelheim and Patrick Sagmeister from Exputec presented at the 4th BioProScale conference in Berlin, Germany, how scale-dependent challenges were overcome for the successful scale-up of a biopharmaceutical manufacturing process and the qualification of scale-down models.